CBD has the potential to interact with many other products, including over-the-counter drugs, herbal products, and prescription drugs. Some medications should never be taken with CBD; other medications may need to be modified or reduced to avoid serious problems. CBD inhibits some enzymes in this family. This causes certain medications to break down more slowly, which may increase side effects unless the doctor adjusts the dose.
On the other hand, CBD induces other enzymes in this family, which accelerates the breakdown of certain drugs, so they may be less effective unless the dose is increased. If you then take CBD while taking these medications, your body can't work to process CBD as effectively. The documented effects of CBD on liver function and enzymes that metabolize several drugs are relevant when considering whether to consume CBD with certain medications or not. However, CBD products that contain more than 0.3 percent THC still fall under the legal definition of marijuana, making them federally illegal but legal under some state laws.
This inhibitory effect on CYP450 enzymes depends primarily on the amount of CBD a person takes, their unique physiology, and the type of CBD used (for example, if you are taking CBD with medications, it is important to be aware of any potential changes in how the medication or CBD affects you. Considering that CBD has so many potential health benefits, you may start to wonder if it can interact with certain medications that are used to treat the same symptoms and whether or not you should take these CBD medications. However, more research is needed to determine the severity of CBD interactions between different drugs and to develop recommendations for taking them together with CBD. More than half said they wanted more information about CBD from their doctor, but 58 percent of those who told their doctors about their CBD use didn't get the information about the safety, effectiveness and dosage they were looking for.
We have very little information about over-the-counter CBD products and how they can interact with other medications, says Dr. That said, this versatility is also why CBD interacts with so many prescription drugs and over-the-counter (OTC) PRODUCTS. A common concern among people with chronic illnesses who use CBD is whether CBD may interfere with prescription medications you may take for arthritis or other conditions. CBD acts on the same metabolites as grapefruit, so many of the prescription drugs that carry grapefruit warning labels may have similar risks when taken with CBD.
While topical CBD products may not be absorbed deeply enough to raise concerns about drug interactions, that also means that they may not be as effective for arthritis pain.